Multiple exposures-response (MER)

It is well recognised that workers are usually exposed to multiple exposures at workplaces and related non-occupational exposure risk factors (e.g., environment, lifestyle, behavioural and socio-economic). The multiple exposure-response relationships that can be captured with the working-life exposome would lay the groundwork for evidence-based and cost-effective preventions, and ultimately improve working life health by reducing the burden of non-communicable diseases. In this tutorial we present an overview of a suite of existing statistical approaches that can be applied to multiple exposure-response modelling in the context of working-life exposome. The basic principles, implementation, pro/cons, and their extensions are discussed and may serve as a useful guide for statistical analyses with multiple exposures.